Unwinding a path to nuclear [beta]-catenin
Article Abstract:
A study was conducted to show that PDGF, a growth factor that induces the transition of epithelial cells to mesenchymal cells, stimulates the c-Abl kinase-dependent phosphorylation of p68 RNA helicase. The findings reveal that phosphorylated p68 dissociates [beta]-catenin from the axin destruction complex resulting to promotion of nuclear [beta]-catenin signaling independent of Wnt activation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
Article Abstract:
The transcription factor Foxo, which is inhibited by the insulin/IGF signaling (IIS), extends life span in conditions of low IIS activity but life span can also be increased by activating the stress-responsive Jun-N-terminal kinase (JNK) pathway. A model to explain the effects of stress and nutrition on longevity provides can be provided by the convergence of JNK signaling and IIS on Foxo.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Antagonizing Wnt and FGF receptors: An enemy from within (the ER)
Article Abstract:
A novel molecule, Shisa that functions in the endoplastic reticulum (ER) to prevent maturation of frizzled (Fz) serpentine receptors and fibroplast growth factor receptor (FGFR) is described. Shisa promotes anterior patterning in Xenopus by antagonizing Wnt and FGF signaling cell-autonomously.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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